[HTML][HTML] Toxicity of fatty acid hydroperoxides towards Yarrowia lipolytica: implication of their membrane fluidizing action

HT Thanh, L Beney, H Simonin, TXS Nguyen… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Linoleic acid hydroperoxide (HPOD), substrate of hydroperoxide lyase, an enzyme of the
lipoxygenase pathway, can be transformed into many aromatic compounds, the so-called
“green notes”. The presence of linoleic acid hydroperoxide in the culture medium of
Yarrowia lipolytica, the yeast expressing the cloned hydroperoxide lyase of green bell
pepper, undoubtedly exerted an inhibition on the growth and a toxic effect with 90% of yeast
cells died after 120 min of exposition in 100 mM HPOD solution. The increase in cell …
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